S H hand1 hand2 handcombind R E
RESEARCH THEME SIX

Understanding The Clinical, Social And Basic Science Of Mpox

Project Leads: Professor Chloe Orkin, Dr Sara Paparini, Ms Maryam Khan

Overview

Mpox became a pandemic in 2022, after having been a neglected disease for 50 years. Novel clinical and epidemiological features were identified and published by SHARE researchers in 2022 and 2023.

The community response was critical to limiting the spread of mpox within sexual networks. Working in partnerships with community organisations to understand their perspectives was vital to tailor interventions to what the community wanted and needed.

Laboratory features of mpox have differed in the recent outbreak. There are many unknowns around re-infection and the levels of immunity in people with natural immunity and in response to the small pox vaccine that was deployed during the 2022/23 pandemic.

‘Because viruses know no borders, the world needs to move cohesively and quickly to close knowledge gaps and to contain the outbreak’

SHARE-NET author group, NEJM 2022

 

Activities

SHARE will collaborate with scientists at the World Health Organisation and in Porten Down to deliver social science research and basic science research. To achieve this, we are:

  • Exploring community perceptions of mpox treatment
  • Establishing laboratory capacity and developing a tissue bank to study the neglected disease HIV-2
  • Investigating virological and immunological factors related to reinfection and post vaccine immunity to mpox

Publications

Publications

 

Storer, D., Holt, M., Paparini, S., Haire, B., Cornelisse, V. J., MacGibbon, J., Broady, T. R., Lockwood, T., Delpech, V., McNulty, A., & Smith, A. K. J. (2024). Informed, but uncertain: Managing transmission risk and isolation in the 2022 mpox outbreak among gay and bisexual men in Australia. Culture, Health & Sexuality, 1–16. https://doi.org/10.1080/13691058.2024.2346540

 

Smith, A. K. J., Storer, D., Lancaster, K., Haire, B., Newman, C. E., Paparini, S., MacGibbon, J., Cornelisse, V. J., Broady, T. R., Lockwood, T., McNulty, A., Delpech, V., & Holt, M. (2024). Mpox Illness Narratives: Stigmatising Care and Recovery During and After an Emergency Outbreak. Qualitative Health Research, 10497323241234482. https://doi.org/10.1177/10497323241234482

 

Hayes, R., Dakin, F., Smuk, M., Paparini, S., Apea, V., Dewsnap, C., Waters, L., Anderson, J., Orkin, C.M., 2024. Cross-sectional survey of sexual health professionals’ experiences and perceptions of the 2022 mpox outbreak in the UK. BMJ Open 14, e080250. Https://doi.org/10.1136/bmjopen-2023-080250

 

Wan, Y.I., Smuk, M., Pearse, R.M., Paparini, S., Apea, V.J., Orkin, C.M. 2023. Clinical research in the NHS: a cross-sectional study of research engagement during the monkeypox pandemic. BMJ Leader 7, e000812. Https://doi.org/10.1136/leader-2023-000812

Paparini, S., Whitacre, R., Smuk, M., Thornhill, J., Mwendera, C., Strachan, S., Nutland, W., Orkin, C., 2023. Public understanding and awareness of and response to monkeypox virus outbreak: A cross-sectional survey of the most affected communities in the United Kingdom during the 2022 public health emergency. HIV Medicine 24, 544–557. Https://doi.org/10.1111/hiv.13430

Orkin, C., Paparini, S., Thornhill, J.P., Apea, V., Mwendera, C.A., Smuk, M., Hayes, R., Anderson, J., 2023. SHARING to create knowledge in a crisis. BMJ Leader 7, e000810. Https://doi.org/10.1136/leader-2023-000810

Paparini, S., Whelan, I., Mwendera, C., Hayes, R., Maatouk, I., Lewis, R., … Orkin, C. (2024). Prevention of sexual transmission of mpox: a systematic review and qualitative evidence synthesis of approaches. Infectious Diseases56(8), 589–605. https://doi.org/10.1080/23744235.2024.2364801

Conferences

 

Storer, D., Holt, M., Paparini, S., Haire, B., MacGibbon, J., Cornelisse, V., Broady, T., Lockwood, T., Delpech, V., McNulty, A., Bourne, A., Heath-Paynter, D., Lancaster, K., Newman, C., Rule, J., Smith, A. K J. ‘Informed, but uncertain: managing transmission risk and isolation in the 2022 mpox outbreak among gay and bisexual men in Australia.’ Oral abstract accepted for the 25th International Union Against Sexually Transmitted Infections (IUSTI) World Congress 2024, Sydney, September 2024.

Smith, A. K J., Storer, D., Lancaster, K., Cornelisse, V., MacGibbon, J., Haire, B., Newman, C., Delpech, V., Paparini, S., Rule, J., McNulty, A., Bourne, A., Broady, T., Heath-Paynter, D., Holt, M. (2023). ‘“It was just the most horrible experience of my life” Understanding social and care experiences during and after mpox illness: Qualitative accounts of people diagnosed and close contacts in Australia.’ Australasian Sexual and Reproductive Health (ASRH) Conference Oral Presentation, 20th September 2023.

Hayes R, Smith AKJ, Apea V, Orkin CM, Paparini S. Outbreak distress: characterising moral distress amongst international healthcare workers responding to mpox in 2022. Oral presentation. BSA Medical Sociology Conference 2023, 13-15 September; Brighton, United Kingdom.

Smith, A. K J., Storer, D., Lancaster, K., Cornelisse, V., MacGibbon, J., Haire, B., Newman, C., Delpech, V., Paparini, S., Rule, J., McNulty, A., Bourne, A., Broady, T., Paynter, H., Holt, M. (2023). ‘“It was just the most horrible experience of my life” Understanding social and care experiences during and after mpox illness: Qualitative accounts of people diagnosed and close contacts in Australia.’ International AIDS Society (IAS) 2023 Conference Latebreaker Oral Presentation, 25th July 2023. https://doi.org/10.1002/jia2.26134

S Paparini, J Thornhill, C Mwendera, S Strachan, R Whitacre, W Nutland, CM Orkin. O41A Perceptions and understandings of media and public health messaging about the monkeypox outbreak in the UK: findings from a rapid response, co-produced survey. Oral presentation. HIV Glasgow 2022, 23–26 October; Glasgow, United Kingdom.

S Paparini, S Strachan, J Thornhill, W Nutland, C Mwendera, CM Orkin. O41B Including women in the public health response to the monkeypox (MPXV) outbreak in the UK: findings from a rapid response, co-produced survey. Oral presentation. HIV Glasgow 2022, 23–26 October; Glasgow, United Kingdom.

 

Get in touch

If you’d like more information about research theme four, please contact the project leads:

Professor Chloe Orkin
Email c.m.orkin@qmul.ac.uk

Dr Sara Paparini
Email s.paparini@qmul.ac.uk

Ms Maryam Khan
Email maryam.khan@qmul.ac.uk