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International Women’s Day: Professor Chloe Orkin on Advocating For Inclusion in HIV Research

To mark this International Women’s Day, we spotlight the imperative need for inclusivity in the field of HIV research. 

Professor Chloe Orkin, who is the Lead for HIV research at Barts Health NHS Trust  and director of the SHARE Collaborative for health equity (and a patron of NHST), has been a staunch advocate for improving representation throughout her career. 

In this short Q&A with NHST, Professor Orkin shares insights on the under-representation of women in this field, and shares perspective on how it can be combatted. 

Tell us about your personal and professional motivation in regards to HIV research?

I am deeply interested in gender politics and am committed to improving the representation of women in clinical trials. It has always been clear to me that the importance of including women in HIV research needs to be underscored and addressed. My career has been and continues to be driven by the need to ensure that research reflects and benefits a diversity of individuals. A clear objective is transforming the landscape of HIV research to be truly representative and inclusive.

What challenges have you encountered in regards to women being adequately represented in clinical trials?

Women have always been under-represented in HIV treatment and that continues to this day. Research I presented only recently at the Conference on Retroviruses and Opportunistic Infections highlighted that in trials for long-acting injectable therapies, women were notably underrepresented with respect to the country proportion of women living with HIV. 

How can such under-representation be addressed?

It requires a particular focus on those who have been historically marginalised. This means not just advocating for more inclusive research, but also designing studies that actively prioritise diverse participation. Effective strategies include intentional recruitment and inclusive protocol design. For instance, the ILANA study I led in the UK recruited over 50% women and people of colour, embedding an approach that countered sexism, racism, and ageism within its protocol.

What guidance would you offer to young researchers or clinicians who want to focus on improving healthcare inclusivity and efficacy for women with HIV?

Remember that patients are not hard to reach, it is our services that are hard to access. We need to tailor our services to what all of our patients need.

You were the global lead author for the FLAIR study which evaluated the first-ever long-acting injectable HIV therapy. Tell us about the key findings, and how they benefited the understanding and treatment of HIV in women.

Women made up around 20% of participants in the FLAIR study. When all the studies in long-acting injectable treatment with Cabotegravir and Rilpivirine (CAB+RPV) were pooled to establish a larger sample of women, there were no differences found between men and women, the treatment was equally effective. Such studies are crucial for developing treatment options that are accessible and effective. Representation is essential to ensure everyone can benefit equally from scientific advancement. 

As a global medical leader for the U=U campaign, do you see this message particularly resonating with women living with HIV, or needing adaptation?

The Undetectable=Untransmittable message is powerful, yet there’s a need for nuanced communication. Some studies have shown that women have been slightly more sceptical of the message. It is also important to say that in breastfeeding the risk is negligible, not zero unlike all other circumstances. Again, tailoring the messaging to patients with specific realities is key.

Looking ahead, how do you envision HIV research and treatment evolving, particularly in relation to women’s health and inclusivity?

Women experience many inequities. Violence against women and girls is a huge factor in determining risk of acquiring HIV, and it is also something that women living with HIV experience. Our services need to be accessible and competent in identifying people affected by VAWG to signpost them to relevant services.  

In terms of research, I hope that the global efforts to include women in trials will be successful. From a treatment point of view, long-acting PrEP has the potential to transform the ability of women to be in control of their HIV prevention options. 

Advances in equitable research and healthcare will overall afford women greater autonomy and control over their health.   

Finally, is it important that medical and academic circles also embrace representation, and where do you see your role within this? 

Representation matters immensely. It’s vital to also embrace inclusion in terms of those who lead and conduct HIV research, as well as those who participate in it. As Billie Jean King said: you have to see it, to be it. As a visible LGBTQ+ advocate, and in roles I’ve held such as President of the Medical Women’s Federation, I try to make sure that younger people see me going about my business and register that there is a place for people like them in medicine and academia too. Diversity on both sides of research and clinical trials will only enrich our understanding and approach to healthcare long-term.

Article Credit: The National HIV Story Trust – https://www.nhst.org.uk/international-womens-day-professor-chloe-orkin-on-advocating-for-inclusion-in-hiv-research/

‘Candour, care, and COVID-19’ – The Lancet Perspective Review

‘Candour, care, and COVID-19’ – Dr Rageshri Dhairyawan Perspective Review for The Lancet

Dr Rageshri Dhairyawan was asked by The Lancet to write a review on the 3-part drama called ‘Breathtaking’ which highlighted the experience of the Covid-19 pandemic on frontline medical staff and how they desperately worked hard to save lives. For the full article, please follow the link here.

Snippet from the review – please follow the link here for the full article on The Lancet

SHARE Collaborative awarded at the Inaugural Research and Innovation awards at Queen Mary

Queen Mary’s Research and Innovation Awards recognise the excellent people and teams that make creative, dynamic and world-class research and innovation possible at Queen Mary.

The awards ceremony, held on 25 May 2023 at the Law Society, brought together nominators nominees and their team members to recognise exceptional work and expertise delivered by teams and individuals from across the university in eight categories. The Research and Innovation awards is to be held annually to recognise the exceptional research conducted at Queen Mary. 

The SHARE collaborative found success during this ceremony by securing two awards for innovative research conducted amongst the team. The categories won were the following:

Research Impact – culture civic and community  

Excellent interdisciplinary research project 

For further information on the remaining categories and other awards won, please follow the link here.